Publications

Elrod, N.D., Henriques, T., Huang, K.-L., Tatomer, D.C., Wilusz, J.E., Wagner, E.J., and Adelman, K. (2019). The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes. Mol Cell 76, 738-752.e7. PMID: 31809743

 

Pai, A.A, Paggi, J., Yan, P., Adelman, K. & Burge, C.B. (2018) Numerous recursive sites contribute to accuracy of splicing in long introns in flies. PLoS Genet. 14 (8): e1007588. PMID: 30148878

 

Henriques, T. & Adelman, K. (2018) Transcriptional speed bumps revealed in high resolution. Nature; 560 (7720): 560-61. PMID: 30143755

 

Henriques, T., Scruggs, B.S., Inouye, M.O., Muse, G.W., Williams, L.H., Burkholder, A.B., Lavender, C.A., Fargo, D.C. & Adelman, K. (2018) Widespread transcriptional pausing and elongation control at enhancers. Genes Dev.; 32 (1): 26-41.        

► Stimulated an Outlook by Tippens, N.D., Vihervaara, A., Lis, J.T. Enhancer transcription: what, where, when, and why? (2018) Genes Dev.; 32 (1): 1-3.    

► Featured in a Research Highlight (Zlotorynski E. Gene expression: Developmental enhancers in action. Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2018.15)

 

Meers, M.P., Adelman, K., Duronio, R.J., Strahl, B.D., McKay, D.J. & Matera, A.G. (2018) Transcription start site profiling uncovers divergent transcription and enhancer-associated RNAs in Drosophila melanogaster. BMC Genomics; 19 (1): 157.

 

Lavender, C.A., Shapiro, A.J., Burkholder, A.B., Bennett, B.D., Adelman, K. & Fargo, D.C. (2017) ORIO (Online Resource for Integrative Omics): a web-based platform for rapid integration of next generation sequencing data. Nucleic Acids Res.; 45 (10):5678-90. PMID: 28402545

 

Meers, M.P., Henriques, T., Lavender, C.A., McKay, D.J., Strahl, B.D., Duronio, R.J., Adelman, K. & Matera, G.A. (2017) Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity. Elife; Mar 27 (6). PMID: 28346137; PubMed Central PMCID: PMC5404926

 

Dorighi, K.M., Swigut, T., Henriques, T., Bhanu, N.V., Scruggs, B.S., Nady, N., Still, C.D., Garcia, B.A., Adelman, K. & Wysocka, J. (2017) Mll3 and Mll4 facilitate enhancer RNA synthesis and transcription from promoters independently of H3K4 monomethylation. Mol Cell; 66 (4): 568-76. PMID: 28483418    

►Featured in a Preview (Pollex, T. & Furlong, E.M, Correlation does not imply causation: histone methyltransferases, but not histone methylation, SET the stage for enhancer activation, Mol Cell; 66 (4): 439-41).

 

Cinghu, S., Yang, P., Kosak, J.P., Conway, A.E., Kumar, D., Oldfield, A.J., Adelman, K. & Jothi, R. (2017) Intragenic enhancers attenuate host gene expression. Mol Cell; 68 (1): 104-17. PMID: 28985501    

► Featured as a Research Highlight (Wrighton, K.H. Transcription: Intragenic enhancers dampen gene expression, Nat. Rev Genet. and Nat. Rev. Mol. Cell Biol. PMID: 29062056)

 

Urban, J., Kuzu, G., Bowman, S., Scruggs, B., Henriques, T., Kingston, R., Adelman, K., Tolstorukov, M. & Larschan, E. (2017) Enhanced chromatin accessibility of the dosage compensated Drosophila male X-chromosome requires the CLAMP zinc finger protein. PLoS One; 12 (10) e0186855. PMID: 29077765

 

Pai, A.A, Henriques, T., Paggi, J., Burkholder, A., Adelman, K. & Burge, C.B. (2017) The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture. Elife; Dec 27;6. pii: e32537. doi: 10.7554/eLife.32537. PMID: 29280736

 

Egan, E. & Adelman, K. (2017) Non-coding RNA: more uses for genomic junk. Nature; 543 (7644): 183-85. PMID: 28277509

 

Scruggs. B.S & Adelman, K. (2015) The importance of controlling transcription elongation at coding and noncoding RNA loci. Cold Spring Harb. Symp. Quant. Biol.; (80) 33-44. PMID: 27325707

 

Scruggs, B.S., Gilchrist, D.A., Nechaev, S., Muse, G.W., Burkholder, A., Fargo, D.C & Adelman, K. (2015) Bidirectional transcription arises from two distinct hubs of transcription factor binding and active chromatin. Mol Cell; 58 (6) 1101-12.  PMCID: PMC4475495    

► First author Benjamin Scruggs featured in the “Meet the Author” section of the Molecular Cell website (http://www.cell.com/molecular-cell/meet-the-author/scruggs)

 

Williams, L.H., Fromm, G., Gokey, N.G., Henriques, T., Muse, G.W., Burkholder, A., Fargo, D.C., Hu, G. & Adelman, K. (2015) Pausing of RNA polymerase II regulates mammalian developmental potential through control of signaling networks. Mol Cell; 58 (2) 311-22.  PMCID: PMC4402150