Publications since 2017

Contributions from lab members are indicated in bold:

 

Robinson DCL, Ritso M, Nelson GM, Mokhtari Z, Nakka K, Bandukwala H, Goldman SR, Park PJ, Mounier R, Chazaud B, Brand M, Rudnicki MA, Adelman K, Dilworth FJ. (2021) Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation. Dev Cell; 56 (7):1014-1029.e7. doi: 10.1016/j.devcel.2021.02.025. PubMed PMID: 33735618.

 

Reimer KA, Mimoso CA, Adelman K & Neugebauer KM (2021) Co-transcriptional splicing regulates 3' end cleavage during mammalian erythropoiesis. Mol Cell; 81 (5): 998-1012.e7. doi: 10.1016/j.molcel.2020.12.018. PMCID: PMC8038867

 

Huang KL, Jee D, Stein CB, Elrod ND, Henriques T, Mascibroda LG, Baillat D, Russell WK, Adelman K & Wagner EJ (2020) Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination. Mol Cell; 80 (2): 345-358.e9. doi: 10.1016/j.molcel.2020.08.016. PMCID: PMC7660970

 

Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Custo Greig E, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E & Zon LI (2020) RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol. 22 (4): 372-379. doi: 10.1038/s41556-020-0493-0. PMCID: PMC7185069

 

Rogers JM, Guo B, Egan ED, Aster JC, Adelman K & Blacklow SC (2020) MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation. Mol Cell Biol. 14; 40 (11). doi: 10.1128/MCB.00014-20. PMCID: PMC7225564

 

Field A & Adelman K (2020) Evaluating Enhancer Function and Transcription. Annu Rev Biochem. doi: 10.1146/annurev-biochem-011420-095916. PMID: 32197056

 

Elrod ND, Henriques T, Huang KL, Tatomer DC, Wilusz JE, Wagner EJ & Adelman K (2019) The Integrator complex attenuates promoter-proximal transcription at protein-coding genes. Mol Cell; 76: 738-752. PMCID: PMC6952639

 

Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, Nechaev S, Whetstine JR, Roeder RG, Adelman K, Goren A & Mostoslavsky R (2019) The histone deacetylase SIRT6 restrains transcription elongation via promoter-proximal pausing. Mol Cell; 75: 683-699. PMCID: PMC6907403

 

Oldfield AJ, Henriques T, Kumar D, Burkholder AB, Cinghu S, Paulet D, Bennett BD, Yang P, Scruggs BS, Lavender CA, Rivals E, Adelman K & Jothi R (2019) NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region. Nat Commun; 10 (1): 3072. PMCID: PMC6624317

 

Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete-Perea J, Sheng W, Gygi SP, Adelman K & Shi Y (2019) PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression. Mol Cell; 75: 620-30. PMCID: PMC6688901

 

Core L & Adelman K (2019) Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation. Genes Dev; 33: 960-982. PMCID: PMC6672056

 

Henriques, T & Adelman, K (2018) Transcriptional speed bumps revealed in high resolution. Nature; 560 (7720): 560-61. PMID: 30143755

 

Henriques T, Scruggs BS, Inouye MO, Muse GW, Williams LH, Burkholder AB, Lavender CA, Fargo DC & Adelman K (2018) Widespread transcriptional pausing and elongation control at enhancers. Genes Dev; 32 (1): 26-41. PMCID: PMC5828392

Stimulated an Outlook: Tippens ND, Vihervaara A & Lis JT, Enhancer transcription: what, where, when, and why? Genes Dev; 32 (1): 1-3.

Featured Research Highlight: Zlotorynski E, Gene expression: Developmental enhancers in action. Nat Rev Mol Cell Biol, doi: 10.1038/nrm.2018.15

Highlighted in Harvard Medical School News: https://hms.harvard.edu/news/remote-control

 

Kaikkonen MU & Adelman K (2018) Emerging roles of non-coding transcription. Trends Biochem Sci; 43 (9): 654-667. PMID: 30145998

 

Meers MP, Henriques T, Lavender CA, McKay DJ, Strahl BD, Duronio RJ, Adelman K & Matera GA (2017) Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity. eLife; Mar 27 (6): e23249 PMCID: PMC5404926

 

Dorighi KM, Swigut T, Henriques T, Bhanu NV, Scruggs BS, Nady N, Still CD, Garcia BA, Adelman K & Wysocka J (2017) Mll3 and Mll4 facilitate enhancer RNA synthesis and transcription from promoters independently of H3K4 monomethylation. Mol Cell; 66 (4): 568-76. PMCID: PMC5662137 

►Featured in a Preview (Pollex T & Furlong EM, Correlation does not imply causation: histone methyltransferases, but not histone methylation, SET the stage for enhancer activation, Mol Cell; 66 (4): 439-41).

 

Cinghu S, Yang P, Kosak JP, Conway AE, Kumar D, Oldfield AJ, Adelman K & Jothi R (2017) Intragenic enhancers attenuate host gene expression. Mol Cell; 68 (1): 104-17. PMCID: PMC5683415   

► Featured as a Research Highlight (Wrighton KH, Transcription: Intragenic enhancers dampen gene expression, Nat. Rev Genet. and Nat. Rev. Mol. Cell Biol. PMID: 29062056)

 

Urban J, Kuzu G, Bowman S, Scruggs BS, Henriques T, Kingston R, Adelman K, Tolstorukov M & Larschan E (2017) Enhanced chromatin accessibility of the dosage compensated Drosophila male X-chromosome requires the CLAMP zinc finger protein. PLoS One; 12 (10): e0186855. PMCID: PMC5659772

 

Pai AA, Henriques T, Paggi J, Burkholder A, Adelman K & Burge CB (2017) The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture. eLife; Dec 27 (6): e32537. PMCID: PMC5762160

 

Egan, E & Adelman, K (2017) Non-coding RNA: more uses for genomic junk. Nature; 543 (7644): 183-85. PMID: 28277509