We study gene regulation in development and how gene activity is perturbed in diseases such as cancer. Using a combination of functional genomics, genetics and biochemistry, we study how transcription is influenced by cellular signaling and how gene expression interfaces with chromatin architecture and epigenetic features of the genome. We also use cutting-edge nascent RNA-sequencing methods to investigate the transcription of protein coding mRNAs and non-coding RNA species such as enhancer RNAs.

News

Emily's paper is published!

Emily

Emily’s story on transcriptional control in spermatogenesis is out. Beautiful work by Emily, in collaboration with Geoff Nelson and the lab of Prabu Reddi. 

Kaye EG, Nelson GM et al. (2024) RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis. Nat Comm; 15(1):848. doi: 10.1038/s41467-024-45177-3  https://www.nature.com/articles/s41467-024-45177-3

Dalton joins the group!

Dalton

We welcome Dalton McGlamery to the team, where he will work with Jessica to develop a cell-free system for studying transcription and RNA processing.