We study gene regulation in development and how gene activity is perturbed in diseases such as cancer. Using a combination of functional genomics, genetics and biochemistry, we study how transcription is influenced by cellular signaling and how gene expression interfaces with chromatin architecture and epigenetic features of the genome. We also use cutting-edge nascent RNA-sequencing methods to investigate the transcription of protein coding mRNAs and non-coding RNA species such as enhancer RNAs.
News
Julia's Paper is out!
Julia’s paper on the mechanisms of transcriptional activation by Notch signaling is now out. Congratulations to Julia and co-authors Claudia and Ben! https://genesdev.cshlp.org/content/38/21-24/965.full?sid=3d78a4bc-75f6-4b2f-8426-fe43dfac7f5c
This work was also highlighted in an Outlook article in Genes & Development: https://genesdev.cshlp.org/content/38/21-24/931.full.pdf+html
Farewell to Claudia!
We are sad to say goodbye to Claudia, but are excited to see what she accomplishes as she starts as an Independent Fellow in the Department of Genetics at the Yale School of Medicine!
Farewell to Ben!
We are sad to see Ben leave the group but are excited to see him step into his new role as an Assistant Professor at the Lady Davis Research Institute and Department of Oncology at McGill University.