We study gene regulation in development and how gene activity is perturbed in diseases such as cancer. Using a combination of functional genomics, genetics and biochemistry, we study how transcription is influenced by cellular signaling and how gene expression interfaces with chromatin architecture and epigenetic features of the genome. We also use cutting-edge nascent RNA-sequencing methods to investigate the transcription of protein coding mRNAs as well as non-coding RNA species.
We're happy to welcome Karla Martinez Nevarez to the lab! Karla is a graduate student in the BBS program, and previously graduated from UC Santa Cruz. In our lab, she will be studying premature termination in the context of external stimuli.