We study gene regulation in development and how gene activity is perturbed in diseases such as cancer. Using a combination of functional genomics, genetics and biochemistry, we study how transcription is influenced by cellular signaling and how gene expression interfaces with chromatin architecture and epigenetic features of the genome. We also use cutting-edge nascent RNA-sequencing methods to investigate the transcription of protein coding mRNAs and non-coding RNA species such as enhancer RNAs.
Claudia's paper on how the Restrictor complex slows elongation rate to render ncRNAs more susceptible to termination has been released in advance in Genes and Development!
It can be found here with advanced access: https://genesdev.cshlp.org/content/early/2025/05/20/gad.352654.125.abstract
