Lab Members

Principal Investigator

Karen Adelman

Harvard Medical School
BCMP, LHRRB Building, Room 201a
45 Shattuck St.
Boston, MA 02115
Email: karen_adelmanathms [dot] harvard [dot] edu

We aim to elucidate how cells react in a rapid yet balanced manner to external signals, at the transcriptional and epigenetic level. We use a combination of genomics, genetics and biochemistry to study the dynamics of gene expression, with a focus on developmental systems and cancer.

Postdoctoral Fellows

Apoorva Baluapuri

Apoorva earned his PhD at the Cancer Systems Biology Lab at University of Würzburg in 2021. Now at the Adelman lab he is interested in learning the mechanisms and modularity of gene regulation by the Integrator complex and to apply these learnings in cancer therapeutics. 

(Maria) Jessica Bruzzone

Jessica is a post-doctoral fellow interested in understanding the mechanisms that govern co-transcriptional processes like RNAPII pausing and splicing.

Emily Kaye

Emily_Kayeathms [dot] harvard [dot] edu

Emily is a post-doctoral fellow interested in fine tuning gene regulation. She has multiple projects, including screening sequence requirements for enhancer activity in the fly and probing protein-protein interactions of the Integrator Complex in human cells.

Ben Martin

benjamin_martinathms [dot] harvard [dot] edu

Ben is a post-doctoral fellow studying the interplay between metabolic and transcriptional changes during cell state transitions, with a focus on the regulation of histone modifications.

Hanneke Vlaming

Hanneke_Vlamingathms [dot] harvard [dot] edu

Hanneke is a post-doctoral fellow interested in uncovering the signals that tell RNA polymerase II when to terminate transcription of non-coding RNAs. She also hopes to understand how the mode of transcription termination is coupled to the processing and stability of nascent non-coding RNAs.

Graduate Students

Eileen Ablondi

efablondiatg [dot] harvard [dot] edu

Eileen is a graduate student in the Biological and Biomedical Sciences (BBS) PhD program. She is interested in understanding how enhancers are established, regulated, and maintained in the context of development. Outside of the lab, she volunteers with HPREP, which provides science programming for underserved high-school students, and DayCon, a day-long science conference for the general public.

Karla Martinez Nevarez

kmartineznevarezatg [dot] harvard [dot] edu

Karla is a graduate student in the Biological and Biomedical Sciences (BBS) PhD Program. She is interested in understanding the mechanisms that terminate transcription and how these mechanisms respond to external signals. Outside of the lab, Karla serves on the board of MBSH and volunteers with HPREP and Science Club for Girls.

Claudia Mimoso

cmimosoatg [dot] harvard [dot] edu

Claudia is a graduate student in the Biological and Biomedical Sciences (BBS) PhD Program. She is interested in the mechanistic roles of trans-acting factors in the regulation of both coding and non-coding RNA termination and decay. Outside of the lab, Claudia serves as a TA for BCMP 200, and is involved with the BCMP Trainee Committee, HGWISE and MBSH. 

Chad Stein

chad_steinatg [dot] harvard [dot] edu

Chad is a graduate student in the Biological and Biomedical Sciences (BBS) PhD program.  He is interested in understanding protein complexes that connect transcriptional regulation to chromatin environments, particularly in development and cancer.  He is also interested in teaching, mentoring, and science communication. 

Research Assistants

Piero Espinel

Piero_Espinelathms [dot] harvard [dot] edu

Piero is a Research Assistant interested in understanding the regulation of RNAPII by kinases and phosphatases. In particular, he is looking to characterize the behavior of transcriptional phosphatases in cancer cells, and develop modulators of phosphatase activity.

ChenCheng Zhao

Chen has joined "Team Integrator" in the lab as a research assistant.

Grants Manager

Emily Egan

Emily_Eganathms [dot] harvard [dot] edu

Emily is a lab manager, working with the Adelman and Blacklow labs.