Lab Members

Principal Investigator

Karen Adelman

Harvard Medical School
BCMP, LHRRB Building, Room 201a
45 Shattuck St.
Boston, MA 02115
Email: karen_adelmanathms [dot] harvard [dot] edu

We aim to elucidate how cells react in a rapid yet balanced manner to external signals, at the transcriptional and epigenetic level. We use a combination of genomics, genetics and biochemistry to study the dynamics of gene expression, with a focus on developmental systems and cancer.

Postdoctoral Fellows

(Maria) Jessica Bruzzone

Jessica is a post-doctoral fellow interested in understanding the mechanisms that govern co-transcriptional processes like RNAPII pausing and splicing.

Andrew Field

Andrew_Fieldathms [dot] harvard [dot] edu

Andrew is a post-doctoral fellow interested in transient cell states that underpin embryonic stem cell differentiation and development. In particular, he is investigating the role of enhancer commissioning and decommissioning in the transition from naive to primed stem cells. He is also probing the importance of specific enhancers and enhancer features at the cellular and mechanistic levels using a combination of bulk, single cell, and biochemical techniques.

Emily Kaye

Emily_Kayeathms [dot] harvard [dot] edu

Emily is a post-doctoral fellow studying the regulation of enhancer activity through transcription factor recruitment and the potential roles of enhancer RNA synthesis. Her current goal is to define sequence requirements of enhancer function using in vivo screens.

Ben Martin

benjamin_martinathms [dot] harvard [dot] edu

Ben is a post-doctoral fellow studying the interplay between metabolic and transcriptional changes during cell state transitions, with a focus on the regulation of histone modifications.

Hanneke Vlaming

Hanneke_Vlamingathms [dot] harvard [dot] edu

Hanneke is a post-doctoral fellow interested in uncovering the signals that tell RNA polymerase II when to terminate transcription of non-coding RNAs. She also hopes to understand how the mode of transcription termination is coupled to the processing and stability of nascent non-coding RNAs.

Graduate Students

Eileen Ablondi

efablondiatg [dot] harvard [dot] edu

Eileen is a fourth-year graduate student in the Biological and Biomedical Sciences (BBS) PhD program. She is interested in understanding how enhancers are established, regulated, and maintained in the context of development. Outside of the lab, she volunteers with HPREP, which provides science programming for underserved high-school students, and DayCon, a day-long science conference for the general public.

Claudia Mimoso

cmimosoatg [dot] harvard [dot] edu

Claudia is a third-year graduate student in the Biological and Biomedical Sciences (BBS) PhD Program. She is interested in the mechanistic roles of trans-acting factors in the regulation of both coding and non-coding RNA termination and decay. Outside of the lab, Claudia serves as a TA for BCMP 200, and is involved with the BCMP Trainee Committee, HGWISE and MBSH. 

Chad Stein

chad_steinatg [dot] harvard [dot] edu

Chad is a third-year graduate student in the Biological and Biomedical Sciences (BBS) PhD program.  He is interested in understanding protein complexes that connect transcriptional regulation to chromatin environments, particularly in development and cancer.  He is also interested in teaching, mentoring, and science communication. 

Grants Manager

Emily Egan

Emily_Eganathms [dot] harvard [dot] edu

Emily is a lab manager, working with the Adelman and Blacklow labs.