Lab members indicated in bold:
Kaye EG, Nelson GM, Zomer HD, Roy D, Joseph II, Adelman K, Reddi PP (2024) RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis. Nat Comm; 15(1):848. doi: 10.1038/s41467-024-45177-3. PMCID: PMC10824759
Wheeler EC*, Martin BJE*, Doyle WC, Neaher S, Conway CA, Pitton CN, Gorelov RA, Donahue M, Jann JC, Abdel-Wahab O, Taylor J, Seiler M, Buonamici S, Pikman Y, Garcia JS, Belizaire R, Adelman K, Tothova Z (2024) Splicing modulators impair DNA damage response and induce killing of cohesin mutant MDS and AML. Science Transl Med; 16(728):eade2774. doi: 10.1126/scitranslmed.ade2774 PMID: 38170787
Martin BJE*, Ablondi EF*, Goglia C, Mimoso CA, Espinel-Cabrera PR, Adelman K (2023) Global identification of SWI/SNF targets reveals compensation by EP400. Cell; 186(24):5290-5307.e26. doi: 10.1016/j.cell.2023.10.006 PMID: 37922899
►Highlighted in Harvard Medical School news: https://hms.harvard.edu/news/one-punch-isnt-enough-overcome-common-cancer-mutation
►Highlighted in Apple news: https://apple.news/AS7Tw_s51SxOKHGc4EBdK-w
Wu G, Yoshida N, Liu J, Zhang X, Xiong Y, Heavican-Foral TB, Mandato E, Liu H, Nelson GM, Yang L, Chen R, Donovan KA, Jones MK, Roshal M, Zhang Y, Xu R, Nirmal AJ, Jain S, Leahy C, Jones KL, Stevenson KE, Galasso N, Ganesan N, Chang T, Wu WC, Louissaint A, Debaize L, Yoon H, Dal Cin P, Chan WC, Ho Sui SJ, Ng SY, Feldman AL, Horwitz SM, Adelman K, Fischer ES, Chen CW, Weinstock DM, Brown M. (2023) TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence. Science Transl Med; 15 (714): eadi7244. doi: 10.1126/scitranslmed.adi7244 PMID: 37729434
Wagner EJ, Tong L, Adelman K (2023) Integrator is a global promoter-proximal termination complex. Mol Cell; S1097-2765(22)01101-7. doi: 10.1016/j.molcel.2022.11.012 PMCID: PMC10866050
Rambout X, Cho H, Blanc R, Lyu Q, Miano JM, Chakkalakal JV, Nelson GM, Yalamanchili HK, Adelman K, Maquat LE (2023) PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII. Mol Cell; 83 (2): 186-202.e11. doi: 10.1016/j.molcel.2022.12.022. PMCID: PMC9951270
Mimoso CA, Adelman K (2023) U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes. Mol Cell; 83 (8): 1264-1279.e10. doi: 10.1016/j.molcel.2023.03.002. PMCID: PMC10135401
Insco ML, Abraham BJ, Dubbury SJ, Kaltheuner IH, Dust S, Wu C, Chen KY, Liu D, Bellaousov S, Cox AM, Martin BJE, Zhang T, Ludwig CG, Fabo T, Modhurima R, Esgdaille DE, Henriques T, Brown KM, Chanock SJ, Geyer M, Adelman K, Sharp PA, Young RA, Boutz PL, Zon LI. (2023) Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science; 380 (6642): eabn7625. doi: 10.1126/science.abn7625. PMCID: PMC10184553
Stein CB, Field AR, Mimoso CA, Huang KL, Wagner EJ, Adelman K (2022) Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II transcribed loci. Mol Cell; S1097-2765 (22) 00961-3. doi: 10.1016/j.molcel.2022.10.004. PMCID: PMC9680917
Luppino JM, Field A, Nguyen SC, Park DS, Shah PP, Abdill RJ, Lan Y, Yunker R, Jain R, Adelman K, Joyce EF (2022) Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression. PLoS Genet; 18 (11): e1010528. doi: 10.1371/journal.pgen.1010528. PMCID: PMC9744307
Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, Shi YG, Adelman K, Lan F, Shi Y, Shen H (2022) Dynamic control of chromatin-associated m 6 A methylation regulates nascent RNA synthesis. Mol Cell; 82 (6): 1156-1168.e7. doi: 10.1016/j.molcel.2022.02.006. PMCID: PMC8969783
Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, Zhang J, Luo Z, Gygi SP, Adelman K, Moazed D (2022) Rixosomal RNA degradation contributes to silencing of Polycomb target genes. Nature; 604 (7904): 167-174. doi: 10.1038/s41586-022-04598-0. PMCID: PMC8986528
Vlaming H, Mimoso CA, Field AR, Martin BJE, Adelman K (2022) Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential. Nat Struct Mol Biol; 29 (6): 613-620. doi: 10.1038/s41594-022-00785-9. PMCID: PMC9672417
Replogle JM, Saunders RA, Pogson AN, Hussmann JA, Lenail A, Guna A, Mascibroda L, Wagner EJ, Adelman K, Bonnar JL, Jost M, Norman TM. Weissman JS (2022) Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Cell; 185 (14): 2559-2575.e28. doi: 10.1016/j.cell.2022.05.013. PMCID: PMC9380471
Mehta S, Buyanbat A, Kai Y, Karayel O, Goldman SR, Seruggia D, Zhang K, Fujiwara Y, Donovan KA, Zhu Q, Yang H, Nabet B, Gray NS, Mann M, Fischer ES, Adelman K, Orkin SH (2022) Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells. Cell Chem Biol; 29 (8): 1273-1287.e8. doi: 10.1016/j.chembiol.2022.06.007. PMCID: PMC9391307
Adelman K (2022) Nascent transcription as a predictor and driver of histone modifications. Nat Genet; 54 (3): 223-24. doi: 10.1038/s41588-021-01004-9. PMID: 35273400
Wu W, Nelson GM, Koch R, Donovan KA, Nowak RP, Heavican-Foral TB, Nirmal AJ, Liu H, Yang L, Duffy J, Powers F, Stevenson KE, Jones M, Ng SY, Wu G, Jain S, Xu R, Amaka S, Trevisani C, Donaldson N, Hagner PR, de Leval L, Gaulard P, Iqbal J, Thakurta A, Fischer ES, Adelman K, Weinstock DM (2022) Overcoming IMiD Resistance in T-cell Lymphomas Through Potent Degradation of ZFP91 and IKZF1. Blood; 139 (13): 2024-37. doi: 10.1182/blood.2021014701 PMCID: PMC8972091
Reimer KA, Mimoso CA, Adelman K, Neugebauer KM (2021) Co-transcriptional splicing regulates 3' end cleavage during mammalian erythropoiesis. Mol Cell; 81 (5): 998-1012.e7. doi: 10.1016/j.molcel.2020.12.018. PMCID: PMC8038867
Martin BJE, Adelman K (2021) ecDNA party bus: Bringing the enhancer to you. Mol Cell; 81 (9): 1866-67. doi: 10.1016/j.molcel.2021.04.017. PMID: 33961776
Robinson DCL, Ritso M, Nelson GM, Mokhtari Z, Nakka K, Bandukwala H, Goldman SR, Park PJ, Mounier R, Chazaud B, Brand M, Rudnicki MA, Adelman K, Dilworth FJ (2021) Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation. Dev Cell; 56 (7):1014-1029.e7. doi: 10.1016/j.devcel.2021.02.025. PMCID: PMC8357161
Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V (2021) A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science; 374 (6571): 1113-1121. doi: 10.1126/science.abe2913 PMCID: PMC8943916