We study gene regulation in development and how gene activity is perturbed in diseases such as cancer. Using a combination of functional genomics, genetics and biochemistry, we study how transcription is influenced by cellular signaling and how gene expression interfaces with chromatin architecture and epigenetic features of the genome. We also use cutting-edge nascent RNA-sequencing methods to investigate the transcription of protein coding mRNAs and non-coding RNA species such as enhancer RNAs.
News
Claudia's paper is out!
Claudia's paper on how the Restrictor complex slows elongation rate to render ncRNAs more susceptible to termination has been released in advance in Genes and Development!
It can be found here with advanced access: https://genesdev.cshlp.org/content/early/2025/05/20/gad.352654.125.abstract
Apoorv's paper is out!
Apoorv'a paper on Integrator loss leading to the formation of dsRNA that triggers the integrated stress response is out in Cell! Congratulations to Apoorv! This work was highlighted in an HMS new article here: https://tinyurl.com/479myryd and spotlights on it were published by Torben Heick Jensen's lab in Cell Chemical Biology (https://doi.org/10.1016/j.chembiol.2025.05.009) and by the Hana Hanzlikova Lab in Molecular Cell (https://doi.org/10.1016/j.molcel.2025.05.024).
Julia's Paper is out!
Julia’s paper on the mechanisms of transcriptional activation by Notch signaling is now out. Congratulations to Julia and co-authors Claudia and Ben! https://genesdev.cshlp.org/content/38/21-24/965.full?sid=3d78a4bc-75f6-4b2f-8426-fe43dfac7f5c
This work was also highlighted in an Outlook article in Genes & Development: https://genesdev.cshlp.org/content/38/21-24/931.full.pdf+html