We study gene regulation in development and how gene activity is perturbed in diseases such as cancer. Using a combination of functional genomics, genetics and biochemistry, we study how transcription is influenced by cellular signaling and how gene expression interfaces with chromatin architecture and epigenetic features of the genome. We also use cutting-edge nascent RNA-sequencing methods to investigate the transcription of protein coding mRNAs and non-coding RNA species such as enhancer RNAs.

News

Apoorv's paper is out!

Apoorv'a paper on Integrator loss leading to the formation of dsRNA that triggers the integrated stress response is out in Cell! Congratulations to Apoorv! This work was highlighted in an HMS new article here: https://tinyurl.com/479myryd and spotlights on it were published by Torben Heick Jensen's lab in Cell Chemical Biology (https://doi.org/10.1016/j.chembiol.2025.05.009) and by the Hana Hanzlikova Lab in Molecular Cell (https://doi.org/10.1016/j.molcel.2025.05.024).