We study gene regulation in development and how gene activity is perturbed in diseases such as cancer. Using a combination of functional genomics, genetics and biochemistry, we study how transcription is influenced by cellular signaling and how gene expression interfaces with chromatin architecture and epigenetic features of the genome. We also use cutting-edge nascent RNA-sequencing methods to investigate the transcription of protein coding mRNAs and non-coding RNA species such as enhancer RNAs.
News
Emily's paper is published!
Emily’s story on transcriptional control in spermatogenesis is out. Beautiful work by Emily, in collaboration with Geoff Nelson and the lab of Prabu Reddi.
Kaye EG, Nelson GM et al. (2024) RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis. Nat Comm; 15(1):848. doi: 10.1038/s41467-024-45177-3
Ben and Eileen's paper is out in Cell!
Congratulations to Ben Martin and Eileen Ablondi for their paper in Cell! It was a ton of work, but we are so proud of you!
Martin BJE*, Ablondi EF* et al. (2023) Global identification of SWI/SNF targets reveals compensation by EP400. Cell; doi: 10.1016/j.cell.2023.10.006 * Co-first authorship
https://hms.harvard.edu/news/one-punch-isnt-enough-overcome-common-cancer-mutation
https://apple.news/AS7Tw_s51SxOKHGc4EBdK-w