Claudia's paper on co-transcriptional splicing is out!

Co-transcriptional splicing regulates 3' end cleavage during mammalian erythropoiesis

Molecular Cell:

Congratulations Claudia!

This important paper shows just how fast mammalian splicing can be, and demonstrates that splicing occurs without Pol II pausing near splice sites. Further, using long-read sequencing Claudia and Kirsten find that failure to splice an RNA molecule causes defects in 3' end formation. 

A wonderful collaboration with Karla Neugebauer's lab!