Co-transcriptional splicing regulates 3' end cleavage during mammalian erythropoiesis
Molecular Cell:
https://doi.org/10.1016/j.molcel.2020.12.018
Congratulations Claudia!
This important paper shows just how fast mammalian splicing can be, and demonstrates that splicing occurs without Pol II pausing near splice sites. Further, using long-read sequencing Claudia and Kirsten find that failure to splice an RNA molecule causes defects in 3' end formation.
A wonderful collaboration with Karla Neugebauer's lab!