Claudia's paper on how the Restrictor complex slows elongation rate to render ncRNAs more susceptible to termination has been released in advance in Genes and Development!
It can be found here with advanced access: https://genesdev.cshlp.org/content/early/2025/05/20/gad.352654.125.abstract
Apoorv'a paper on Integrator loss leading to the formation of dsRNA that triggers the integrated stress response is out in Cell! Congratulations to Apoorv! This work was highlighted in an HMS new article here: https://tinyurl.com/479myryd and spotlights on it were published by Torben Heick Jensen's lab in Cell Chemical Biology (https://doi.org/10.1016/j.chembiol.2025.05.009) and by the Hana Hanzlikova Lab in Molecular Cell (https://doi.org/10.1016/j.molcel.2025.05.024).
Julia’s paper on the mechanisms of transcriptional activation by Notch signaling is now out. Congratulations to Julia and co-authors Claudia and Ben! https://genesdev.cshlp.org/content/38/21-24/965.full?sid=3d78a4bc-75f6-4b2f-8426-fe43dfac7f5c
This work was also highlighted in an Outlook article in Genes & Development: https://genesdev.cshlp.org/content/38/21-24/931.full.pdf+html
We are sad to say goodbye to Claudia, but are excited to see what she accomplishes as she starts as an Independent Fellow in the Department of Genetics at the Yale School of Medicine!
We are sad to see Ben leave the group but are excited to see him step into his new role as an Assistant Professor at the Lady Davis Research Institute and Department of Oncology at McGill University.
Emily’s story on transcriptional control in spermatogenesis is out. Beautiful work by Emily, in collaboration with Geoff Nelson and the lab of Prabu Reddi.
Kaye EG, Nelson GM et al. (2024) RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis. Nat Comm; 15(1):848. doi: 10.1038/s41467-024-45177-3
Congratulations to Ben Martin and Eileen Ablondi for their paper in Cell! It was a ton of work, but we are so proud of you!
Martin BJE*, Ablondi EF* et al. (2023) Global identification of SWI/SNF targets reveals compensation by EP400. Cell; doi: 10.1016/j.cell.2023.10.006 * Co-first authorship
https://hms.harvard.edu/news/one-punch-isnt-enough-overcome-common-cancer-mutation
https://apple.news/AS7Tw_s51SxOKHGc4EBdK-w
We welcome Dalton McGlamery to the team, where he will work with Jessica to develop a cell-free system for studying transcription and RNA processing.
Farewell to Emily Kaye, who leaves us to join Editas. Congratulations on the fantastic position!
We are so proud of Chad and his absolutely beautiful thesis defense. Wow!
Best of luck in your postdoc at UC Berkeley!